Lithium Hydroxide → 2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid
Reaction equation
C[O:2][C:3]([C:5]1[CH:28]=[CH:27][C:8]2[N:9]([CH3:26])[C:10]([NH:12][C:13]3[S:14][C:15]4[CH:21]=[C:20]([S:22]([CH3:25])(=[O:24])=[O:23])[CH:19]=[CH:18][C:16]=4[N:17]=3)=[N:11][C:7]=2[CH:6]=1)=[O:4].[Li+].[OH-]>>[CH3:25][S:22]([C:20]1[CH:19]=[CH:18][C:16]2[N:17]=[C:13]([NH:12][C:10]3[N:9]([CH3:26])[C:8]4[CH:27]=[CH:28][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=4[N:11]=3)[S:14][C:15]=2[CH:21]=1)(=[O:23])=[O:24]Participants
3
Procedure
2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid (1.75 g) was prepared by following General Procedure E starting from 2-(6-methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid methyl ester (2.08 g), and LiOH (10.0 ml, 2.0 N solution in water). LC/MS: m/z 404.
Sources & evidence
- ORD record
- ord-8b10c63877de44e4aa3bc0537498ecda
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08759535B2
Reaction notes
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