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HRID410904

反应详情

EQUATION

反应方程式

HRID 410904 的结构方程式

REACTANTS

反应物

4
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：Nc1nc2ccc(OC(F)(F)F)cc2s1
HCID5070

6-(Trifluoromethoxy)-2-Benzothiazolamine

C8H5F3N2OS

结构：S=C(n1ccnc1)n1ccnc1
HCID80264

Thiocarbonyldiimidazole

C7H6N4S

结构：COCCNc1ccc(C(=O)OC)cc1N
HCID50742440

未命名化合物

PRODUCTS

生成物

1
结构：COCCn1c(Nc2nc3ccc(OC(F)(F)F)cc3s2)nc2cc(C(=O)OC)ccc21
HCID86656849

未命名化合物

收率 49.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

1-(2-Methoxy-ethyl)-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (829.0 mg) was prepared by following General Procedure D starting from 3-amino-4-(2-methoxy-ethylamino)-benzoic acid methyl ester (800.0 mg), 2-amino-6-(trifluoromethoxy)benzothiazole (930.0 mg), 1,1′-thiocarbonyldiimidazole (700.0 mg), and EDC (770.0 mg) in DMF (8.0 mL).