HCID 86656889, compound → HCID 86656891, compound

HRID 410972Notes

Reaction equation

HRID 410972 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][N:11]1[C:15]2[CH:16]=[CH:17][C:18]([C:20](=[O:28])[NH:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])=[CH:19][C:14]=2[N:13]=[C:12]1[NH:29][C:30]1[S:31][C:32]2[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:33]=2[N:34]=1)C)(C)(C)C>Cl.O1CCOCC1>[ClH:39].[ClH:39].[OH:27][CH2:26][CH2:25][O:24][CH2:23][CH2:22][NH:21][C:20]([C:18]1[CH:17]=[CH:16][C:15]2[N:11]([CH2:10][CH2:9][NH:7][CH3:6])[C:12]([NH:29][C:30]3[S:31][C:32]4[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:33]=4[N:34]=3)=[N:13][C:14]=2[CH:19]=1)=[O:28]

Participants

4

Reactant 1

HCID 86656889HCID 86656889, compound

Product 1

HCID 86656891HCID 86656891, compoundYield 258.5%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-(2-methylamino-ethyl)-1H-benzoimidazole-5-carboxylic acid [2-(2-hydroxy-ethoxy)-ethyl]-amide dihydrochloride (60 mg) was prepared by following General Procedure L starting from (2-{2-(6-chloro-benzothiazol-2-ylamino)-5-[2-(2-hydroxy-ethoxy)-ethylcarbamoyl]-benzoimidazol-1-yl}-ethyl)-methyl-carbamic acid tert-butyl ester (73 mg) in 4M HCl in dioxane (1 mL). LC/MS: m/z 488.5.

Sources & evidence

ORD record
ord-6384aecae1c1497299ca6f5621b2f1ea
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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