HCID 86656957, compound → HCID 86656921, compound

HRID 411035Notes

Reaction equation

HRID 411035 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@@H:10]([NH:13][C:14]([C:16]2[CH:36]=[CH:35][C:19]3[N:20]([CH3:34])[C:21]([NH:23][C:24]4[S:25][C:26]5[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:27]=5[N:28]=4)=[N:22][C:18]=3[CH:17]=2)=[O:15])[CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:33].[ClH:33].[NH:8]1[CH2:12][CH2:11][C@@H:10]([NH:13][C:14]([C:16]2[CH:36]=[CH:35][C:19]3[N:20]([CH3:34])[C:21]([NH:23][C:24]4[S:25][C:26]5[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:27]=5[N:28]=4)=[N:22][C:18]=3[CH:17]=2)=[O:15])[CH2:9]1

Participants

4

Reactant 1

HCID 86656957HCID 86656957, compound

Product 1

HCID 86656921HCID 86656921, compoundYield 258.8%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

2-(6-Chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid (R)-pyrrolidin-3-ylamide dihydrochloride (45 mg) was prepared by following General Procedure L starting from (R)-3-{[2-(6-chloro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carbonyl]-amino}-pyrrolidine-1-carboxylic acid tert-butyl ester (55 mg) in 4M HCl in dioxane (1 mL).

Sources & evidence

ORD record
ord-11e5089567c44ab6b0eb42ec7db84799
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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