1,2-Dichloroethane → HCID 86656973, compound

HRID 411059Notes

Reaction equation

HRID 411059 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.[CH3:12][O:13][C:14](=[O:34])[C:15]1[CH:20]=[CH:19][C:18]([NH:21][CH2:22][CH2:23][N:24]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH3:25])=[C:17]([NH2:33])[CH:16]=1.[CH2:35](Cl)CCl>CN(C=O)C>[CH3:12][O:13][C:14]([C:15]1[CH:20]=[CH:19][C:18]2[N:21]([CH2:22][CH2:23][N:24]([C:26]([O:28][C:29]([CH3:31])([CH3:30])[CH3:32])=[O:27])[CH3:25])[C:35]([NH:9][C:7]3[S:8][C:4]4[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:5]=4[N:6]=3)=[N:33][C:17]=2[CH:16]=1)=[O:34]

Participants

5

Reactant 3

HCID 111,2-DichloroethaneHCID 72266-Chloro-2-benzothiazolamineHCID 67332848HCID 67332848, compound

Product 1

HCID 86656973HCID 86656973, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-[2-(tert-Butoxycarbonyl-methyl-amino)-ethyl]-2-(6-chloro-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (1.9 g) was prepared by following General Procedure D starting from 6-chloro-benzothiazol-2-ylamine (920 mg), 3-amino-4-[2-(tert-butoxycarbonyl-methyl-amino)-ethylamino]-benzoic acid methyl ester (1.4 g), thioCDI (900 mg) and EDC (960 mg) in DMF (15 mL).

Sources & evidence

ORD record
ord-27a5fea392b24e25922f57d6b595138b
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

Loading…