反应详情

温度

100 °C

20 g of the 2-(2-methoxymethyl-4-nitrophenoxy)acetamide made in step 1 are dissolved in 55 ml of N-methylpyrrolidone, mixed with 29 g of potassium carbonate and heated for 3 hours at 100° C. Subsequently the reaction mixture is cooled to room temperature and the solvent is removed in vacuum at 60 to 80° C. The remaining residue is crystallized by addition of 100 ml water. 8.8 g of a yellowish product are obtained with a melting point of 90 to 92° C.

1. temperatureSubsequently the reaction mixture is cooled to room temperature
2. customthe solvent is removed in vacuum at 60 to 80° C
3. customThe remaining residue is crystallized by addition of 100 ml water