Acetone → HCID 18539770, compound

HRID 411108Notes

Reaction equation

HRID 411108 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][CH2:4][C:3]=1[C:7]([CH3:10])([CH3:9])[CH3:8].[CH3:11]C(C)=O.N1CCCC1.[CH2:20](O)[CH3:21]>CO>[C:7]([C:3]1[C:2](=[CH2:1])[C:6]([CH3:11])=[C:5]([CH3:4])[C:20]=1[CH3:21])([CH3:8])([CH3:9])[CH3:10]

Participants

6

Reactant 4

HCID 180AcetoneHCID 702EthanolHCID 31268PyrrolidineHCID 18539774HCID 18539774, compound

Product 1

HCID 18539770HCID 18539770, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
-78 °C

Procedure

In a 500 ml flask is placed 12.60 g of the product obtained in step B and dissolved in 40 ml of methanol. The mixture is cooled down to −78° C. 2.15 g acetone in 10 ml of ethanol is added slowly. In the next step 4 g of pyrrolidine in 10 ml of methanol is added. After six hours the reaction is terminated by addition of 10 ml of acetic acid. After separation of organic phase, drying, evaporation of solvents and distillation an orange oil is obtained (8.95 g).

Workup

  1. customIn a 500 ml flask is placed
  2. customAfter six hours the reaction is terminated by addition of 10 ml of acetic acid
  3. customAfter separation of organic phase
  4. customdrying
  5. customevaporation of solvents and distillation an orange oil
  6. customis obtained (8.95 g)

Sources & evidence

ORD record
ord-5590f37583a74e1b85b117f6f93457a5
Source dataset
uspto-grants-2003_05
Patent number
US06559089B1

Reaction notes

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