反应详情

4-(Oxiranylmethoxy)benzonitrile (from step (i) above; 100 g, 0.57 mol) was added to a mixture of concentrated aqueous ammonium hydroxide (500 mL) and iso-propanol (300 mL). The resulting slurry was stirred at room temperature for 3 days. The reaction mixture was filtered to remove the insoluble by-product, and the filtrate was concentrated in vacuo to give a crude product, which was crystallised from acetonitrile to yield 50 g (46%) of the sub-title compound.

1. filtrationThe reaction mixture was filtered
2. customto remove the insoluble by-product
3. concentrationthe filtrate was concentrated in vacuo
4. customto give a crude product, which
5. customwas crystallised from acetonitrile