反应详情

A mixture containing 46 (0.294 g, 0.757 mmol), paratoluensolfonic acid (0.005 g), i-butanol (1.0 mL) and benzene (4.0 mL) was heated to reflux for 12 h. The reaction mixture was then concentrated and the residue so obtained was purified by silica gel column chromatography using 5% of methanol in dichloromethane as eluent, obtaining the desired compound. Yield: 81%.

1. temperaturewas heated
2. temperatureto reflux for 12 h
3. concentrationThe reaction mixture was then concentrated
4. customthe residue so obtained
5. customwas purified by silica gel column chromatography