Lansoprazole → HCID 10128985, compound

HRID 411614Notes

Reaction equation

HRID 411614 reaction equation
[CH3:1][C:2]1[C:3]([CH2:14][S:15]([C:17]2[NH:21][C:20]3[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=3[N:18]=2)=[O:16])=[N:4][CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].C(N(CC)CC)C.Cl[S:34]([C:37]1[CH:42]=[CH:41][C:40]([NH:43][C:44]([NH2:46])=[O:45])=[CH:39][CH:38]=1)(=[O:36])=[O:35]>ClCCl>[CH3:1][C:2]1[C:3]([CH2:14][S:15]([C:17]2[N:18]([S:34]([C:37]3[CH:38]=[CH:39][C:40]([NH:43][C:44]([NH2:46])=[O:45])=[CH:41][CH:42]=3)(=[O:36])=[O:35])[C:19]3[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=3[N:21]=2)=[O:16])=[N:4][CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:11])[F:12]

Participants

5

Reactant 3

HCID 3883LansoprazoleHCID 8471TriethylamineHCID 27608894-UREIDO-BENZENESULFONYL CHLORIDE

Product 1

HCID 10128985HCID 10128985, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole (185 mg) dissolved in 30 ml of dichloromethane and 0.4 ml of triethylamine was added to 128 mg of N-[4-(chlorosulfonyl)phenyl]urea. The reaction mixture was stirred at room temperature overnight. The reaction mixture was washed with water and 0.1N sodium bicarbonate solution.

Workup

  1. washThe reaction mixture was washed with water and 0.1N sodium bicarbonate solution

Sources & evidence

ORD record
ord-96d30534e1294c18bfb274f277025208
Source dataset
uspto-grants-2003_05
Patent number
US06559167B1

Reaction notes

Loading…