反应详情

温度

25 °C

NaOH 2N (0.398 mL, 0.80 mmol) was added to methyl 8-[(2R)-(1-(3-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylate (120 mg, 0.27 mmol) in a mixture of THF (2.4 mL) and MeOH (2.4 mL). The resulting solution was stirred at 25° C. over the weekend. HCl aq was added until pH ˜2. The solvents were removed under vacuum and the yellow solid was collected by filtration, washed with Diethyl ether to give 8-[(2R)-(1-(3-fluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid (100 mg, 86%). Mass Spectrum: m/z [M+H]+=439.

1. customThe solvents were removed under vacuum
2. filtrationthe yellow solid was collected by filtration
3. washwashed with Diethyl ether