反应详情

温度

90 °C

To a degassed solution of the product from Step I (11.4 g, 55.6 mmol) in 100 mL of DMF was added Zn(CN)2 (3.92 g, 33.4 mmol) and Pd(PPh3)4 (5.1 g, 4.45 mmol). The reaction was stirred at 90° C. overnight, cooled to room temperature, and concentrated in vacuo. Purification of this material by silica gel chromatography (50% EtOAc/hexane) provided the titled product as a light yellow solid.

1. temperaturecooled to room temperature
2. concentrationconcentrated in vacuo
3. customPurification of this material by silica gel chromatography (50% EtOAc/hexane)