反应详情

温度

50 °C

To a solution of the the product from Step E (954 mg, 2.23 mmol) in 7 mL of methanol and 7 mL of DMSO was added triethylamine (1.56 mL, 11.2 mmol), Pd(OAc)2 (25.1 mg, 0.11 mmol), and 1,3-bis-(diphenylphosphine)propane (46 mg, 0.11 mmol). The reaction was heated at 50° C. under an atmosphere of carbon monoxide for 3 hours, and cooled to room temperature. The solution was poured into water and extracted with 3× dichloromethane. The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuo to give the product which was used without further purification.

1. temperaturecooled to room temperature
2. extractionextracted with 3× dichloromethane
3. dry with materialThe combined organic extracts were dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customto give the product which
7. customwas used without further purification