反应详情

To a solution of the the product from Step F (802 mg, 2.23 mmol) in 50 mL of THF was added 10 mL of 2N NaOH solution, and the reaction was heated at reflux overnight. The solution was acidified with 1N HCl and extracted with 3× EtOAc. The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuo to give a solid, which was triturated with dichloromethane to give the titled product.

1. temperaturethe reaction was heated
2. temperatureat reflux overnight
3. extractionextracted with 3× EtOAc
4. dry with materialThe combined organic extracts were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customto give a solid, which
8. customwas triturated with dichloromethane