Hydrochloric Acid → HCID 135550619, compound

HRID 412293Notes

Reaction equation

HRID 412293 reaction equation
[NH2:1][C:2]1[C:7]([CH2:8][S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:6]([CH:16]2[CH2:21][CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17]2)[CH:5]=[C:4]([C:29]2[C:34]([O:35]CC3C=CC(OC)=CC=3)=[CH:33][CH:32]=[CH:31][C:30]=2[O:45][CH2:46][CH:47]2[CH2:49][CH2:48]2)[N:3]=1.[ClH:50]>O1CCOCC1.C(OCC)(=O)C>[ClH:50].[NH2:1][C:2]1[N:3]=[C:4]([C:29]2[C:30]([O:45][CH2:46][CH:47]3[CH2:49][CH2:48]3)=[CH:31][CH:32]=[CH:33][C:34]=2[OH:35])[CH:5]=[C:6]([CH:16]2[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]2)[C:7]=1[CH2:8][S:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22258865HCID 22258865, compound

Product 1

HCID 135550619HCID 135550619, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of tert-butyl 3-{2-amino-6-{2-(cyclopropylmethoxy)-6-[(4-methoxybenzyl)oxy]phenyl}-3-[(phenylsulfanyl)methyl]-4-pyridinyl}-1-piperidinecarboxylate in 1,4-dioxane (2 mL) was added 4N HCl in dioxane (2 mL). The mixture was stirred at room temperature overnight, and diluted with ethyl acetate. The resulting precipitate was collected by filtration, washed with ethanol, and dried under reduced pressure to give 2-[6-amino-5-[(phenylsulfanyl)methyl]4-(3-piperidinyl)-2-pyridinyl]-3-(cyclopropylmethoxy)phenol hydrochloride.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethanol
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-d76e8df2582c447a9b49d6a8a23c7852
Source dataset
uspto-grants-2003_05
Patent number
US06562811B1

Reaction notes

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