反应详情

To a dichloromethane (50 mL) mixture of 3-methoxy-1-propanol (2.70 g, 30.0 mmol) and triethylamine (4.62 mL, 33.0 mmol), was added methanesulfonyl chloride (2.45 mL, 31.5 mmol) while stirring on ice, and the resulting mixture was stirred at room temperature for 30 minutes. Water and ethyl acetate were added to the reaction mixture. After thoroughly shaking the mixture, the organic layer was separated, and the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The mixture was filtered, and the solvent in the filtrate was then distilled off under reduced pressure.

1. stirringthe resulting mixture was stirred at room temperature for 30 minutes
2. stirringAfter thoroughly shaking the mixture
3. customthe organic layer was separated
4. washthe organic layer was washed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationThe mixture was filtered
7. distillationthe solvent in the filtrate was then distilled off under reduced pressure