Chloroform → HCID 18536351, compound

HRID 412555Notes

Reaction equation

HRID 412555 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[CH:37]=[CH:36][C:17]([O:18][CH2:19][C:20]3[N:24]([CH2:25][CH2:26][O:27][CH3:28])[C:23]4[CH:29]=[CH:30][C:31]([C:33]([NH2:35])=[NH:34])=[CH:32][C:22]=4[N:21]=3)=[CH:16][CH:15]=2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O.C(Cl)(Cl)[Cl:46]>>[ClH:46].[ClH:46].[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[CH:15]=[CH:16][C:17]([O:18][CH2:19][C:20]3[N:24]([CH2:25][CH2:26][O:27][CH3:28])[C:23]4[CH:29]=[CH:30][C:31]([C:33]([NH2:35])=[NH:34])=[CH:32][C:22]=4[N:21]=3)=[CH:36][CH:37]=2)[CH2:9]1

Participants

4

Reactant 3

HCID 6212ChloroformHCID 6422Trifluoroacetic acidHCID 18536493HCID 18536493, compound

Product 1

HCID 18536351HCID 18536351, compound

Procedure

To a solution of 2-[4-(1-tert-butoxycarbonylpyrrolidin-3-yloxy)-phenoxymethyl]-1-(2-methoxyethyl)benzimidazole-5-carboxamidine (115 mg) in chloroform (3 ml) was added trifluoroacetic acid (3 ml), and the mixture was stirred at 5 min. The solvent was evaporated and to the obtained residue was added 1N hydrogen chloride-diethyl ether (2 ml). The solvent was evaporated and the obtained residue was washed with tetrahydrofuran and dried under reduced pressure to give the title compound (97 mg).

Workup

  1. customThe solvent was evaporated and to the obtained residue
  2. additionwas added 1N hydrogen chloride-diethyl ether (2 ml)
  3. customThe solvent was evaporated
  4. washthe obtained residue was washed with tetrahydrofuran
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-30085777569c4c47a7989964cfa71d08
Source dataset
uspto-grants-2003_05
Patent number
US06562828B1

Reaction notes

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