反应详情

To a solution of 3-[4-[4-(1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-yl]pyridin-3-yl]-2-propenoic acid ethyl ester (70 mg) in dimethylformamide (1 ml) were added diisopropylethylamine (0.032 ml) and 1H-pyrazole-1-carboxamidine hydrochloride (27 mg), and the mixture was stirred at room temperature for 12 hours. The solvent was evaporated and to the obtained residue was added diethyl ether and the supernatant was removed. This procedure was repeated twice and hydrogen chloride-ethanol solution was added to the obtained residue and insoluble material was removed. The solution was concentrated and dried under reduced pressure to give the title compound (50 mg).

1. customThe solvent was evaporated and to the obtained residue
2. additionwas added diethyl ether
3. customthe supernatant was removed
4. additionhydrogen chloride-ethanol solution was added to the obtained residue and insoluble material
5. customwas removed
6. concentrationThe solution was concentrated
7. customdried under reduced pressure