Hydrogen Bromide → 1,2,3,4-Tetrahydroisoquinolin-6-ol--hydrogen bromide (1/1)

HRID 412579Notes

Reaction equation

HRID 412579 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[BrH:13]>>[BrH:13].[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 393566-Methoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 133617991,2,3,4-Tetrahydroisoquinolin-6-ol--hydrogen bromide (1/1)

Procedure

6-Methoxy-1,2,3,4-tetrahydroisoquinoline (2.89 g) was dissolved in 48% aqueous hydrogen bromide solution (70 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and to the obtained residue were added ethanol and diethyl ether. The mixture was filtrated and dried under reduced pressure to give the title compound (3.93 g).

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was evaporated and to the obtained residue
  3. additionwere added ethanol and diethyl ether
  4. filtrationThe mixture was filtrated
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-45378efb71f6493387a5248cd1d3c7af
Source dataset
uspto-grants-2003_05
Patent number
US06562828B1

Reaction notes

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