反应详情

To a solution of 4-carbamoylpiperidine-1-carboxylic acid tert-butyl ester (5.6 g) in a mixture of tetrahydrofuran (110 ml) and carbon tetrachloride (90 ml) was added triphenylphosphine (24.4 g), and the mixture was stirred under reflux for 1.5 hours. After completion of the reaction, the reaction mixture was filtrated and the solvent was evaporated. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) and dried under reduced pressure to give the title compound (3.5 g).

1. temperatureunder reflux for 1.5 hours
2. customAfter completion of the reaction
3. filtrationthe reaction mixture was filtrated
4. customthe solvent was evaporated
5. customThe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1)
6. customdried under reduced pressure