反应详情

To a solution of 7-methoxynaphthalene-2-carbonitrile (6 g) in chlorobenzene (60 ml) was added aluminum chloride (15.3 g) at room temperature and the mixture was heated under refluxing for 30 min. After completion of the reaction, the reaction mixture was ice-cooled and ice, ethyl acetate and conc. hydrochloric acid were added, and the mixture was stirred. The organic layer was separated and concentrated. To the obtained residue was added hexane and the resultant solid was collected by filtration and dried under reduced pressure to give the title compound (5.21 g).

1. temperaturethe mixture was heated
2. temperatureunder refluxing for 30 min
3. customAfter completion of the reaction
4. temperaturecooled
5. customThe organic layer was separated
6. concentrationconcentrated
7. additionTo the obtained residue was added hexane
8. filtrationthe resultant solid was collected by filtration
9. customdried under reduced pressure