HCID 11226240, compound → HCID 11191164, compound

HRID 412596Notes

Reaction equation

HRID 412596 reaction equation
[ClH:1].Cl.C([O:5][C:6]([C:8]1([CH2:20][O:21][C:22]2[CH:23]=[CH:24][C:25]3[CH2:31][CH2:30][CH2:29][N:28]([C:32](=[NH:34])[NH2:33])[CH2:27][C:26]=3[CH:35]=2)[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])C>Cl>[ClH:1].[ClH:1].[C:32]([N:28]1[CH2:29][CH2:30][CH2:31][C:25]2[CH:24]=[CH:23][C:22]([O:21][CH2:20][C:8]3([C:6]([OH:7])=[O:5])[CH2:13][CH2:12][N:11]([C:14]4[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=4)[CH2:10][CH2:9]3)=[CH:35][C:26]=2[CH2:27]1)(=[NH:33])[NH2:34]

Participants

3

Reactant 1

HCID 11226240HCID 11226240, compound

Product 1

HCID 11191164HCID 11191164, compoundYield 197.2%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4-(2-Amidino-2,3,4,5-tetrahydro-1H-benz[c]azepin-8-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester dihydrochloride (150 mg) was dissolved in 6N-hydrochloric acid (2 ml), and the mixture was stirred under reflux for 3 hours. After completion of the reaction, insoluble material was removed and the solvent was evaporated. The residue was dried under reduced pressure to give the title compound (140 mg).

Workup

  1. temperatureunder reflux for 3 hours
  2. customAfter completion of the reaction, insoluble material
  3. customwas removed
  4. customthe solvent was evaporated
  5. customThe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-00f79e2f56014a74b8bf67c14f45b8c8
Source dataset
uspto-grants-2003_05
Patent number
US06562828B1

Reaction notes

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