反应详情

To a solution of 3,4-diaminobenzonitrile (474 mg), 4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetic acid (1.25 g) in tetrahydrofuran (50 ml) was added 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroxyquinoline (1.06 g) with ice-cooling, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, the solvent was evaporated and to the obtained residue were added chloroform and hexane. The resultant solid was collected by filtration and dried under reduced pressure to give the title compound (1.55 g).

1. temperaturecooling
2. customAfter completion of the reaction
3. customthe solvent was evaporated and to the obtained residue
4. additionwere added chloroform and hexane
5. filtrationThe resultant solid was collected by filtration
6. customdried under reduced pressure