反应详情

温度

80 °C

To a suspension of 1-(pyridin-4-yl)piperidine-4-carboxylic acid (11.18 g) and triethylamine (11.3 ml) in dimethylformamide (110 ml) was added diphenylphosphoryl azide (12.9 ml) at room temperature, and the mixture was stirred at 80° C. for 30 min. Benzyl alcohol (6.17 ml) was added at the same temperature, and the mixture was stirred for 12 hours. After completion of the reaction, the solvent was evaporated and the obtained residue was purified by silica gel column chromatography (chloroform:methanol=99:1-95:5) and dried under reduced pressure to give the title compound (9.46 g).

1. stirringthe mixture was stirred for 12 hours
2. customAfter completion of the reaction
3. customthe solvent was evaporated
4. customthe obtained residue was purified by silica gel column chromatography (chloroform:methanol=99:1-95:5)
5. customdried under reduced pressure