反应详情

温度

70 °C

The mixture of 5 eq. phosphorous acid and β-alanine is heated to form a melt. Morpholine (1 eq.) is slowly added. The reaction is cooled to about 70° C. and 2 eq. of PCl3 are added. The mixture is heated for about 3.5 hours. Then the reaction is hydrolyzed in aqueous acid at about 75° C. for about 0.5 hours. Crystallization from aqueous acid/IPA, affords pamidronate.

1. temperatureis heated
2. customto form a melt
3. temperatureThe mixture is heated for about 3.5 hours
4. customCrystallization from aqueous acid/IPA