Hydrochloric Acid → HCID 13825051, compound

HRID 412896Notes

Reaction equation

HRID 412896 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.C(OCC)(=O)C>[ClH:24].[F:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:15])=[O:16])=[CH:22][CH:21]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11024351tert-Butyl 4-(4-fluorobenzene-1-sulfonyl)piperidine-1-carboxylate

Product 1

HCID 13825051HCID 13825051, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

1-tert-Butoxycarbonyl-4-(4-fluorophenylsulfonyl)piperidine (1.76 g, 5.1 mmol) was suspended in methanol (10 mL). To the suspension was added 4N-hydrogen chloride in ethyl acetate (20 mL), and the mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated under reduced pressure, and to the concentrate was added ethyl acetate. The precipitates were collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the titled compound (1.39 g, 5.0 mmol, Yield 97%) as white crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionto the concentrate was added ethyl acetate
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with ethyl acetate
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-c6e6bea652254e63bcbcd9cb304e2ff5
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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