Hydrochloric Acid → HCID 18538843, compound

HRID 412950Notes

Reaction equation

HRID 412950 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([N:10]([CH2:23][CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][CH:29]([CH2:32][C:33]3[CH:38]=[CH:37][C:36]([C:39]4[N:40]=[N:41][N:42](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[N:43]=4)=[CH:35][CH:34]=3)[CH2:28][CH2:27]2)[C:11]([CH:13]2[CH2:18][CH2:17][N:16]([S:19]([CH3:22])(=[O:21])=[O:20])[CH2:15][CH2:14]2)=[O:12])[CH:6]=[CH:7][C:8]=1[Cl:9]>C(OCC)(=O)C.C(OCC)(=O)C.CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([N:10]([CH2:23][CH2:24][CH2:25][N:26]2[CH2:27][CH2:28][CH:29]([CH2:32][C:33]3[CH:34]=[CH:35][C:36]([C:39]4[N:40]=[N:41][NH:42][N:43]=4)=[CH:37][CH:38]=3)[CH2:30][CH2:31]2)[C:11]([CH:13]2[CH2:14][CH2:15][N:16]([S:19]([CH3:22])(=[O:20])=[O:21])[CH2:17][CH2:18]2)=[O:12])[CH:6]=[CH:7][C:8]=1[Cl:9]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18538705HCID 18538705, compound

Product 1

HCID 18538843HCID 18538843, compoundYield 194.7%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 21584119Ethylacetate methanolSolvent

Procedure

A solution of 4N hydrogen chloride in ethyl acetate (15 ml) was to a solution of the title compound of example 357 (263 mg, 0.3 mmol) in ethyl acetate-methanol (2/5, 7 ml) and this solution was stirred at room temperature for 1 h. The resulting mixture was concentrated in vacuo. The residue was crystallized from methanol-ethyl acetate (1/1) to give the title compound (196 mg, 97%) as colorless crystalline powder.

Workup

  1. concentrationThe resulting mixture was concentrated in vacuo
  2. customThe residue was crystallized from methanol-ethyl acetate (1/1)

Sources & evidence

ORD record
ord-9da5e0ce0ed94338ad97eb7e13d27e97
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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