Hydrochloric Acid → HCID 18538803, compound

HRID 412954Notes

Reaction equation

HRID 412954 reaction equation
[NH2:1][C:2]([C:4]1[CH:40]=[CH:39][C:7]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][N:18]([C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[CH:32]=3)[C:19]([CH:21]3[CH2:26][CH2:25][N:24]([S:27]([CH3:30])(=[O:29])=[O:28])[CH2:23][CH2:22]3)=[O:20])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1)=[O:3].Cl>CO.C(OCC)(=O)C>[ClH:37].[NH2:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][N:18]([C:31]3[CH:36]=[CH:35][C:34]([Cl:37])=[C:33]([Cl:38])[CH:32]=3)[C:19]([CH:21]3[CH2:26][CH2:25][N:24]([S:27]([CH3:30])(=[O:28])=[O:29])[CH2:23][CH2:22]3)=[O:20])[CH2:13][CH2:14]2)=[CH:39][CH:40]=1)=[O:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 5275762HCID 5275762, compound

Product 1

HCID 18538803HCID 18538803, compoundYield 160.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the title compound of example 362 (195.3 mg, 0.32 mmol) in methanol (20 ml) was added a solution of 4N hydrogen chloride in ethyl acetate (0.4 ml) at room temperature. The resulting solution was concentrated in vacuo. The residue was crystallized from ethanol (10 ml) to give the title compound (165.6 mg, 80%) as colorless crystalline powder.

Workup

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customThe residue was crystallized from ethanol (10 ml)

Sources & evidence

ORD record
ord-97722bd660eb4898ada133a4aec6a04a
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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