1,1'-Carbonyldiimidazole → HCID 15484057, compound

HRID 413244Notes

Reaction equation

HRID 413244 reaction equation
[F:1][C:2]([F:15])([F:14])[S:3]([C:6]1[CH:7]=[C:8]([NH2:13])[C:9]([NH2:12])=[CH:10][CH:11]=1)(=[O:5])=[O:4].C1N=CN([C:21](N2C=NC=C2)=[O:22])C=1>CC#N>[F:15][C:2]([F:14])([F:1])[S:3]([C:6]1[CH:11]=[CH:10][C:9]2[NH:12][C:21](=[O:22])[NH:13][C:8]=2[CH:7]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 20634624-(Trifluoromethanesulfonyl)benzene-1,2-diamine

Product 1

HCID 15484057HCID 15484057, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Reflux 4-trifluoromethylsulfonyl-benzene-1,2-diamine (420 mg) and CDI (284 mg) for 16 hours in CH3CN (30 mL). Evaporate the solvent in vacuo. Purify by flash chromatography (1:1 hexanes/EtOAc) to obtain 5-trifluoromethylsulfonyl-1,3-dihydro-benzimidazol-2-one.

Workup

  1. customEvaporate the solvent in vacuo
  2. customPurify by flash chromatography (1:1 hexanes/EtOAc)

Sources & evidence

ORD record
ord-b8635cf9297b484db8243aa3db62d5d2
Source dataset
uspto-grants-2003_05
Patent number
US06566367B2

Reaction notes

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