反应详情

To a suspension of 5-(3-methoxyphenyl)-2-aminobenzoic acid (2.0g) in 1,4-dioxane (20 mL) add N-methylpyrolidinone (NMP, 5 mL) and triethylamine (1.4 mL), followed by diphenyl phosphoric azide (DPPA, 2.5 g). After stirring at ambient temperature for 30 minutes, heat the mixture to 100° C. for 2 hours, until gas evolution fully subsided. Cool the mixture to ambient temperature and concentrate in vacuo. Dissolve the residue in MeOH and leave to stand for 18 hours. Filter the precipitate and air dry to obtain 5-(3-methoxyphenyl)benzimidazolidin-2-one as a pale yellow solid.

1. temperatureheat the mixture to 100° C. for 2 hours
2. temperatureCool the mixture to ambient temperature
3. concentrationconcentrate in vacuo
4. dissolutionDissolve the residue in MeOH
5. customleave
6. waitto stand for 18 hours
7. filtrationFilter the precipitate and air
8. customdry