反应详情

To a solution of sodium bicarbonate (21.5 g, 0.256 mol) in water (150 ml) at 0° C. was added hydroxylamine hydrochloride (8.8 g, 0.127 mol). The reaction mixture was tirred for 30 min. and phenylchloroformate (60 g, 0.383 mol) was introduced directly into the vigorously stirred mixture. Sodium bicarbonate (32.3 g, 3.85 mol) in water (300 ml) was added to the mixture. The mixture was stirred for 30 min., the ice-bath removed and stirring continued for an additional 2 h at room temperature. The resultant suspension was filtered and the filter cake washed with water. The wet filter cake was collected, suspended in hexane, filtered and again washed with hexane. The solid was kept at 0° C. overnight to afford N,O-bis-phenoxycarbonylhydroxylamine (23.5 g, 68%) as a solid. Melting point: 80-82° C. 1H NMR (CDCl3, 200 MHz): δ 7.26(m, 5H), 7.42 (m, 5H) and 8.54 (s, 1H).

1. customthe ice-bath removed
2. stirringstirring
3. waitcontinued for an additional 2 h at room temperature
4. filtrationThe resultant suspension was filtered
5. washthe filter cake washed with water
6. customThe wet filter cake was collected
7. filtrationfiltered
8. washagain washed with hexane
9. waitThe solid was kept at 0° C. overnight