反应详情

温度

80 °C

To a suspension of 8.75 g (0.0314 mole) of 5-bromo-2-phenyl-pyrimidine-4-carboxylic acid in 69 mL of concentrated ammonium hydroxide was added 0.39 g of copper (II) sulfate in 1.6 mL water. The mixture was sealed and heated to 80° C. for 6 days. After cooling to room temperature, and filtration, the solid was taken in 100 ml boiling water, filtered, cooled and acidified with acetic acid. Filtration and drying yielded 4.40 g of 5-amino-2-phenyl-pyrimidine-4-carboxylic acid as a tan solid, mp. 199-202° C.

1. customThe mixture was sealed
2. temperatureAfter cooling to room temperature
3. filtrationfiltration
4. filtrationfiltered
5. temperaturecooled
6. filtrationFiltration
7. customdrying