反应详情

3-Methylsulfonylaniline hydrochloride (5.8 mmol, 1.2 g), 2-benzoyl-4-oxo-pentanoic acid ethyl ester (5.8 mmol, 1.44 g), triethylamine (5.8 mmol, 0.61 g), and tosic acid (0.1 g) were combined in ethanol, then heated under reflux. The resulting oil was resuspended in chloroform, then washed with water, 5% sodium bicarbonate, and brine. The organic layer was dried over NaSO4, then the solids were separated and solvents removed under vacuum. The crude material was purified over silica to yield the named product (m.p. 131° C.-133° C.).

1. temperatureheated
2. temperatureunder reflux
3. washwashed with water, 5% sodium bicarbonate, and brine
4. dry with materialThe organic layer was dried over NaSO4
5. customthe solids were separated
6. customsolvents removed under vacuum
7. customThe crude material was purified over silica