反应详情

A mixture of 2-nitrophenol (0.7 g), powdery potassium carbonate (0.7 g), methyl 2,5-dibromovalerate (1.37 g) and dimethylformamide (10 ml) was stirred at room temperature for 4 hours, to which was added ice-water, followed by extraction with ether. The ether layer was washed with water and dried (MgSO4), then the solvent was distilled off. The residue was purified by means of silica gel chromatography [eluted with hexane-ethyl acetate (1:4)] to obtain methyl 5-bromo-2-(2-nitrophenoxy)valerate as an oily product. The yield was 1.30 g (77.8%).

1. extractionfollowed by extraction with ether
2. washThe ether layer was washed with water
3. dry with materialdried (MgSO4)
4. distillationthe solvent was distilled off
5. customThe residue was purified by means of silica gel chromatography [eluted with hexane-ethyl acetate (1:4)]