反应详情

23 g (1 mol) of sodium are dissolved in 1 litre of ethyl alcohol and 101 g (1.2 mol) of cyanoacetamide are added thereto. 167.5 g (1 mol) of o-chlorobenzyl azide are added to this suspension at 40°-45° and the whole is heated for 2 hours under reflux. After cooling to 30°, 1000 ml of water are added, the precipitated product is filtered off with suction and then washed several times with warm water. After recrystallisation from dioxan and toluene, 5-amino-1-(o-chlorobenzyl)-1H-1,2,3-triazole-4-carboxamide is obtained in the form of colourless crystals having a melting point of 206°-207°.

1. temperaturethe whole is heated for 2 hours
2. temperatureunder reflux
3. temperatureAfter cooling to 30°
4. filtrationthe precipitated product is filtered off with suction
5. washwashed several times with warm water
6. customAfter recrystallisation from dioxan and toluene