Trifluoroacetic acid → HCID 21282593, compound

HRID 414100Notes

Reaction equation

HRID 414100 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](O)([CH3:11])[CH3:10].FC(F)(F)C(O)=O.[NH:20]=[N+:21]=[N-:22]>CCCCCC>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]([N:20]=[N+:21]=[N-:22])([CH3:11])[CH3:10]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 24530Hydrazoic acidHCID 10844911HCID 10844911, compound

Product 1

HCID 21282593HCID 21282593, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

20.6 g (120 millimoles) of 2-(2,6-difluorophenyl)propan-2-ol are dissolved in 300 ml of hydrazoic acid solution (1N, in benzene) and 22.8 g (200 millimoles) of trifluoroacetic acid are added to this solution. After 24 hours at room temperature, the reaction solution is diluted with 500 ml of hexane, washed with water and then with sodium bicarbonate until free of acid and dried over sodium sulfate. The solvent is removed by evaporation and the residue is distilled, affording 2-(2,6-difluorophenyl)-2-azidopropane of bp15 =85°-87° C.

Workup

  1. washwashed with water
  2. dry with materialwith sodium bicarbonate until free of acid and dried over sodium sulfate
  3. customThe solvent is removed by evaporation
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-5dae7528008548be8b2604bdf757f5c7
Source dataset
uspto-grants-1988_12
Patent number
US04789680

Reaction notes

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