反应详情

To a solution of 150 ml of diborane (1M in THF) in 250 ml of dry THF. Ten g of 1-indane carboxamide is slowly added. Reaction mixture is stirred at reflux for three hours, cooled to room temperature, and worked up by slowly adding 150 ml of 1N HCl. THF is distilled off under reduced pressure, the aqueous solution is brought to pH~13 by addition of NaOH. It is extracted with ethyl acetate (2×300 ml). The organic extract is washed with water (1×100 ml), dried over MgSO4, filtered, and evaporated to dryness affording 6.5 g (71%) of 1-indanylmethylamine. It was used as is in the next reaction.

1. customReaction mixture
2. temperatureat reflux for three hours
3. distillationTHF is distilled off under reduced pressure
4. additionthe aqueous solution is brought to pH~13 by addition of NaOH
5. extractionIt is extracted with ethyl acetate (2×300 ml)
6. extractionThe organic extract
7. washis washed with water (1×100 ml)
8. dry with materialdried over MgSO4
9. filtrationfiltered
10. customevaporated to dryness