Hydrochloric Acid → (1H-indene-3-yl)methylamine hydrochloride

HRID 414178Notes

Reaction equation

HRID 414178 reaction equation
O[C:2]1([CH2:11][NH2:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[ClH:13]>C(O)C>[ClH:13].[CH2:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]([CH2:11][NH2:12])=[CH:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 143486951-(aminomethyl)-2,3-dihydro-1H-inden-1-ol

Product 1

HCID 14348696(1H-indene-3-yl)methylamine hydrochlorideYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Two and three-tenth g of 1-hydroxyindanylmethylamine is dissolved in 100 ml of ethanol saturated with HCl . Reaction mixture is refluxed overnight. It is cooled to room temperature and volatiles are evaporated under reduced pressure. The residue is stirred with 300 ml anhydrous ether. Precipitated solid is filtered and dried affording 2.2 g (85%) of the (1H-indene-3-yl)methylamine hydrochloride having a melting point of 245° C. decomp.

Workup

  1. customReaction mixture
  2. temperatureis refluxed overnight
  3. customvolatiles are evaporated under reduced pressure
  4. customPrecipitated solid
  5. filtrationis filtered
  6. customdried

Sources & evidence

ORD record
ord-d92c469402694c57b0e870cd7160263c
Source dataset
uspto-grants-1988_12
Patent number
US04791103

Reaction notes

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