Pyrrolidine → HCID 21282412, compound

HRID 414364Notes

Reaction equation

HRID 414364 reaction equation
[C:1]([O:7][CH3:8])(=[O:6])/[CH:2]=[CH:3]/[CH2:4][CH3:5].[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1>>[N:9]1([CH:3]([CH2:4][CH3:5])[CH2:2][C:1]([O:7][CH3:8])=[O:6])[CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 5364718Methyl 2-pentenoate

Product 1

HCID 21282412HCID 21282412, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 171 g of methyl 2-trans-pentenoate and 106.5 g of pyrrolidine was heated for 20 hours at 100° C. After distillation over a Vigreux column, 198.7 g (72% of theory) of methyl 3-pyrrolidinovalerate of boiling point 65° C./0.4 mbar, nD20 =1.4580, were obtained.

Workup

  1. distillationAfter distillation over a Vigreux column, 198.7 g (72% of theory) of methyl 3-pyrrolidinovalerate of boiling point 65° C./0.4 mbar
  2. customnD20 =1.4580, were obtained

Sources & evidence

ORD record
ord-8c83315f67fe41fc94a1e1befc7c9c9c
Source dataset
uspto-grants-1988_12
Patent number
US04791220

Reaction notes

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