Dimethylformamide → Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

HRID 414367Notes

Reaction equation

HRID 414367 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C)C=O.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:21])=[O:5]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

Product 1

HCID 10999320Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

Procedure

A solution of 2,3-dichloro-4,5-difluorobenzoic acid (9.3 g) and dimethylformamide (0.013 ml) in thionyl chloride (40 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation in nitrogen atmosphere to give the title compound (8.7 g) as pale yellow oil, bp 123°-126° C./40 mmHg.

Workup

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation in nitrogen atmosphere

Sources & evidence

ORD record
ord-2cf3c5da3c9a43c6a773405b46f75f3b
Source dataset
uspto-grants-1988_12
Patent number
US04791225

Reaction notes

Loading…