Hydrochloric Acid → HCID 178522720, compound

HRID 414458Notes

Reaction equation

HRID 414458 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1.[OH:16][CH:17]1[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]1.Cl>C(O)C>[OH:16][CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([C:2]2[N:7]=[C:6]([C:8]([NH:10][C:11]3[NH:15][N:14]=[N:13][N:12]=3)=[O:9])[CH:5]=[N:4][CH:3]=2)[CH2:18]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 232933-HydroxypiperidineHCID 178522716HCID 178522716, compound

Product 1

HCID 178522720HCID 178522720, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 20 ml of ethanol, 1.52 g of 3-hydroxypiperidine was added, and the mixture was refluxed for 6 hours. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 0.93 g of the desired compound as yellow crystals, m.p. 257°-259° C. (decomp.).

Workup

  1. additionwas added
  2. temperaturethe mixture was refluxed for 6 hours
  3. filtrationThe precipitate was collected by filtration
  4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 0.93 g of the desired compound as yellow crystals, m.p. 257°-259° C. (decomp.)

Sources & evidence

ORD record
ord-9ffb94b5df934330bfd4b5e32c64e217
Source dataset
uspto-grants-1988_12
Patent number
US04792547

Reaction notes

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