反应详情

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 20 ml of ethanol, 1.52 g of 3-hydroxypiperidine was added, and the mixture was refluxed for 6 hours. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 0.93 g of the desired compound as yellow crystals, m.p. 257°-259° C. (decomp.).

1. additionwas added
2. temperaturethe mixture was refluxed for 6 hours
3. filtrationThe precipitate was collected by filtration
4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 0.93 g of the desired compound as yellow crystals, m.p. 257°-259° C. (decomp.)