反应详情

To a suspension of 2.26 of 6-chloro-N-(1H-5-tetrazolyl) pyrazine-2-carboxamide in 30 ml of ethanol, 5.55 ml of N-methylpiperazine was added, and the mixture was refluxed for 6 hours. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 1. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 2.27 g of the desired compound as pale yellow crystals, m.p. 246°-250 ° C. (decomp.).

1. additionwas added
2. temperaturethe mixture was refluxed for 6 hours
3. filtrationThe precipitate was collected by filtration
4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 2.27 g of the desired compound as pale yellow crystals, m.p. 246°-250 ° C. (decomp.)