Hydrochloric Acid → HCID 178480775, compound

HRID 414461Notes

Reaction equation

HRID 414461 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1.Cl.[CH2:17](O)[CH3:18]>CN1CCNCC1>[OH2:9].[ClH:1].[CH3:5][N:4]1[CH2:18][CH2:17][N:7]([C:2]2[N:7]=[C:6]([C:8]([NH:10][C:11]3[NH:15][N:14]=[N:13][N:12]=3)=[O:9])[CH:5]=[N:4][CH:3]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178522716HCID 178522716, compound

Product 1

HCID 178480775HCID 178480775, compound

Reagents, catalysts & solvents 1

HCID 531671-MethylpiperazineSolvent

Procedure

To a suspension of 2.26 of 6-chloro-N-(1H-5-tetrazolyl) pyrazine-2-carboxamide in 30 ml of ethanol, 5.55 ml of N-methylpiperazine was added, and the mixture was refluxed for 6 hours. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 1. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 2.27 g of the desired compound as pale yellow crystals, m.p. 246°-250 ° C. (decomp.).

Workup

  1. additionwas added
  2. temperaturethe mixture was refluxed for 6 hours
  3. filtrationThe precipitate was collected by filtration
  4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 2.27 g of the desired compound as pale yellow crystals, m.p. 246°-250 ° C. (decomp.)

Sources & evidence

ORD record
ord-fceef0a681e34db6800969d1ee60f9ae
Source dataset
uspto-grants-1988_12
Patent number
US04792547

Reaction notes

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