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0 °C

7.30 g (27.6 mmol) of 5-(2,3,4-trimethoxyphenyl)-2,4-pentadienoic acid was dissolved in 300 ml of dry dichloromethane and 3.85 ml (27.6 mmol) of triethylamine was added thereto in the atmosphere of argon, and the mixture was stirred at 0° C. To the resulting mixture was added 2.64 ml (27.6 mmol) of ethylcarbonyl chloride followed by stirring for 1 hour and adding 9.59 g (33 mmol) of 4,4'-difluorobenzhydrylpiperazine in 50 ml of dry dichloromethane. Temperature of the mixture was raised to room temperature followed by stirring for additional 16 hours. After addition of water, the mixture was extracted with dichloromethane. The organic layer was washed successively with aqueous 1N-hydrochloric acid solution, a saturated aqueous sodium chloride solution, a saturated aqueous hydrogen carbonate solution and a saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. There was obtained a residue, which was subjected to column chromatography on silica gel to give 10.6 g (20 mmol) of 1-(4,4'-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienoyl)piperazine from eluates of ethyl acetate-hexane (1:1).

1. stirringby stirring for 1 hour
2. temperatureTemperature of the mixture was raised to room temperature
3. stirringby stirring for additional 16 hours
4. extractionthe mixture was extracted with dichloromethane
5. washThe organic layer was washed successively with aqueous 1N-hydrochloric acid solution
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure
8. customThere was obtained a residue, which