3-Bromopyridine → HCID 14373283, compound

HRID 414565Notes

Reaction equation

HRID 414565 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7][CH2:6]2)#[CH:2].Br[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl>[N:17]1[CH:18]=[CH:19][CH:20]=[C:15]([C:2]#[C:1][C:3]2[CH:4]=[C:5]3[C:10](=[CH:11][CH:12]=2)[NH:9][C:8](=[O:13])[CH2:7][CH2:6]3)[CH:16]=1

Participants

4

Reactant 2

HCID 122863-BromopyridineHCID 143732916-ethynyl-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 14373283HCID 14373283, compound

Reagents, catalysts & solvents 1

HCID 6102075Dichlorobis(triphenylphosphine)palladiumCatalyst

Procedure

A mixture of 11.6 mg of cuprous iodide, 86 mg of bis (triphenylphosphine)palladium(II)dichloride, 1.0 g of 6-ethynyl-3,4-dihydrocarbostyril and 3-bromopyridine were reacted as shown in Example 9, and the product isolated in a similar fashion, giving 6-[2-(3-pyridyl)ethynyl]-3,4-dihydrocarbostyril, m.p. 195°-197° C.

Workup

  1. customwere reacted
  2. customthe product isolated in a similar fashion

Sources & evidence

ORD record
ord-1737355dbf564e0c984b894b66592f38
Source dataset
uspto-grants-1988_12
Patent number
US04792561

Reaction notes

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