Hydrochloric Acid → 6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride

HRID 414571Notes

Reaction equation

HRID 414571 reaction equation
C(O)(=O)C.[N:5]1([CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]3)[CH:9]=[CH:8][N:7]=[CH:6]1.[ClH:24]>CO>[ClH:24].[N:5]1([CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]3)[CH:9]=[CH:8][N:7]=[CH:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 198546086-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril acetate

Product 1

HCID 198547386-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril acetate (1.0 g) is dissolved in 50 ml of methanol and a stoichiometric amount of a solution of hydrochloric acid in methanol is added. The solvent is removed under vacuum and the residue recrystallised from a mixture of methanol and ethyl acetate to yield 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride.

Workup

  1. customThe solvent is removed under vacuum
  2. customthe residue recrystallised from a mixture of methanol and ethyl acetate

Sources & evidence

ORD record
ord-04014dc515f34e7791ab7d5edfc64f36
Source dataset
uspto-grants-1988_12
Patent number
US04792561

Reaction notes

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