Hydrochloric Acid → 4-[([1,1'-Biphenyl]-4-yl)oxy]butan-1-amine--hydrogen chloride (1/1)

HRID 414619Notes

Reaction equation

HRID 414619 reaction equation
[ClH:1].[C:2]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])=[CH:4][CH:3]=1.C(OCC)C>CO>[ClH:1].[C:2]1([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13957280HCID 13957280, compound

Product 1

HCID 139572814-[([1,1'-Biphenyl]-4-yl)oxy]butan-1-amine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A twofold stoichiometric excess of 3% hydrochloric acid in methanol is added to a methanolic solution of 1.0 g. of 4-(4-biphenyloxy)-1-aminobutane. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized to give 4-(4-biphenyloxy)-1-aminobutane hydrochloride, m.p. 202°-205° C.

Workup

  1. filtrationThe product is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized

Sources & evidence

ORD record
ord-a13de8ef933b41629c9f4289901c9ff5
Source dataset
uspto-grants-1988_12
Patent number
US04792570

Reaction notes

Loading…