Potassium Carbonate → HCID 13957280, compound

HRID 414620Notes

Reaction equation

HRID 414620 reaction equation
Cl.[C:2]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[C:2]1([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 139572814-[([1,1'-Biphenyl]-4-yl)oxy]butan-1-amine--hydrogen chloride (1/1)

Product 1

HCID 13957280HCID 13957280, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 4-(4-biphenyloxy)-1-aminobutane hydrochloride suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 4-(4-biphenyloxy)-1-aminobutane as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-935f77006a134f998740a44b49023a2e
Source dataset
uspto-grants-1988_12
Patent number
US04792570

Reaction notes

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