反应详情

4-Methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 3 (18.0 g, 84.8 mmol) was dissolved in DMF (50 mL), N,N-Dimethylformamidedimethylacetal (22.5 mL, 170 mmol) and stirred at reflux for 3 hours. Then mixture was concentrated, the residue was dissolved in TCM, washed with water, dried, filtered, and concentrated. The product was purified by crystallization from ether to yield in a colorless solid (14.0 g, 52.5 mmol, 62%).

1. temperatureat reflux for 3 hours
2. concentrationThen mixture was concentrated
3. dissolutionthe residue was dissolved in TCM
4. washwashed with water
5. customdried
6. filtrationfiltered
7. concentrationconcentrated
8. customThe product was purified by crystallization from ether