Acetyl chloride → HCID 135995134, compound

HRID 414994Notes

Reaction equation

HRID 414994 reaction equation
[O:1]=[C:2]1[NH:7][C:6]([CH2:8][C:9]2[CH:13]=[CH:12][S:11][CH:10]=2)=[N:5][C:4]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[C:3]1[C:20]#[N:21].C(N(CC)CC)C.[C:29](Cl)(=[O:31])[CH3:30]>CN(C=O)C.ClCCl>[C:29]([N:17]1[CH2:16][CH2:15][N:14]([C:4]2[N:5]=[C:6]([CH2:8][C:9]3[CH:13]=[CH:12][S:11][CH:10]=3)[NH:7][C:2](=[O:1])[C:3]=2[C:20]#[N:21])[CH2:19][CH2:18]1)(=[O:31])[CH3:30]

Participants

6

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 135995116HCID 135995116, compound

Product 1

HCID 135995134HCID 135995134, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

50 mg (0.17 mmol) of 6-oxo-4-(piperazin-1-yl)-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are dissolved together with 34 mg (0.33 mmol) of triethylamine in DMF and stirred with 14.3 mg (0.18 mmol) of acetyl chloride at RT overnight. The mixture is then diluted with dichloromethane and washed with water. The organic phase is separated off and dried over sodium sulphate and the residue is flash-chromatographed on silica gel (mobile phase: dichloromethane/methanol 100:1, 80:1, 60:1). 42 mg (74% of theory) of the title compound are obtained.

Workup

  1. washwashed with water
  2. customThe organic phase is separated off
  3. dry with materialdried over sodium sulphate
  4. customthe residue is flash-chromatographed on silica gel (mobile phase: dichloromethane/methanol 100:1, 80:1, 60:1)

Sources & evidence

ORD record
ord-7e05a6e939e24dfbaaee19cef4e9d928
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

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