Dimethyl Sulfoxide → HCID 86628495, compound

HRID 41501Notes

Reaction equation

HRID 41501 reaction equation
CS(C)=O.[CH3:5][S:6]([OH:9])(=[O:8])=[O:7].[CH3:10][C:11]1[CH:19]=[C:18]([C:20]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]3[C:38]4[C:33](=[CH:34][C:35]([O:41][CH3:42])=[C:36]([O:39][CH3:40])[CH:37]=4)[N:32]=[C:31]([NH:43][CH3:44])[N:30]=3)[CH:24]=2)=[O:21])[CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>CC(O)C>[CH3:5][S:6]([OH:9])(=[O:8])=[O:7].[CH3:10][C:11]1[CH:19]=[C:18]([C:20]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]3[C:38]4[C:33](=[CH:34][C:35]([O:41][CH3:42])=[C:36]([O:39][CH3:40])[CH:37]=4)[N:32]=[C:31]([NH:43][CH3:44])[N:30]=3)[CH:24]=2)=[O:21])[CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]

Participants

5

Reactant 3

HCID 679Dimethyl Sulfoxide2×HCID 6395Methanesulfonic AcidHCID 66646296methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

Product 1

HCID 86628495HCID 86628495, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Dimethyl sulfoxide (1 mL) and methanesulfonic acid (22 μL) were added to methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (98.58 mg). Dimethyl sulfoxide (1.5 mL) was added to and dissolved in the mixture while heating the mixture, and then 2-propanol (15 mL) was added to the mixture and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (119.47 mg).

Workup

  1. dissolutiondissolved in the mixture
  2. temperaturewhile heating the mixture
  3. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-a8ea3717f72f4184a8eff9afb50dd6f9
Source dataset
uspto-grants-2013_09
Patent number
US08530654B2

Reaction notes

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